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Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

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Antidiarrhetic loperamide hydrochloride.

Jürgen Brüning¹, Dragica Podgorski, Edith Alig

¹University of Frankfurt, Institute of Inorganic and Analytical Chemistry, Frankfurt am Main, Germany.

Acta Crystallographica. Section C, Crystal Structure Communications

|March 3, 2012

Summary

This summary is machine-generated.

Single crystals of a novel piperidinium chloride compound were synthesized. Structural analysis revealed hydrogen bonds and C-H...Cl interactions forming chains and layers, explaining the crystal

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Area of Science:

Crystallography
Supramolecular Chemistry

Background:

The title compound is a piperidinium chloride derivative.
Understanding the crystal structure is crucial for its potential applications.

Purpose of the Study:

To determine the crystal structure of the anhydrous form of 1-[3-(dimethylcarbamoyl)-3,3-diphenylpropyl]-4-hydroxy-4-(4-chlorophenyl)piperidin-1-ium chloride.
To elucidate the intermolecular interactions governing crystal packing and morphology.

Main Methods:

Single crystal X-ray diffraction.
Crystal growth via diffusion of acetone into a 2-propanol solution.

Main Results:

The anhydrous form of the title compound crystallizes as C(29)H(34)ClN(2)O(2)(+)·Cl(-).
N-H...Cl(-) and O-H...Cl(-) hydrogen bonds form chains along the c-axis.
Intermolecular C-H...Cl(-) contacts connect chains into layers parallel to the (100) planes.

Conclusions:

The crystal structure is characterized by hydrogen bonding and C-H...Cl interactions.
These interactions dictate the formation of chains and layers, influencing the plate-like crystal habit.