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Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Types of Intermediate Filaments01:31

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The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...

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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Published on: May 17, 2024

Granulofilamentous meningioma.

Yoshiteru Miyajima1, Hidehiro Oka, Satoshi Utsuki

  • 1Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa 252-0374, Japan. y_miya@fc4.so-net.ne.jp

Brain Tumor Pathology
|March 3, 2012
PubMed
Summary

This study describes a rare granulofilamentous meningioma, a benign brain tumor subtype. Distinguishing it from rhabdoid meningiomas is crucial due to subtle microscopic differences.

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Area of Science:

  • Neurosurgery
  • Pathology
  • Oncology

Background:

  • Meningiomas are tumors arising from the meninges, the membranes surrounding the brain and spinal cord.
  • Benign meningiomas are common, but certain subtypes with specific microscopic features require careful differentiation.
  • Hearing impairment can be an atypical presenting symptom for meningiomas.

Observation:

  • A 55-year-old female presented with hearing impairment, leading to the discovery of a falx meningioma.
  • Surgical resection via an interhemispheric approach successfully removed the encapsulated tumor.
  • Microscopic examination revealed tumor cells with eosinophilic inclusions composed of 12 nm filaments and eccentric nuclei.

Findings:

  • The tumor was histologically classified as a benign meningioma with eosinophilic inclusions.
  • Electron microscopy confirmed the inclusions were intermediate filaments, characteristic of granulofilamentous meningioma.
  • No signs of malignancy were observed in the resected specimen.

Implications:

  • Accurate differentiation between granulofilamentous and rhabdoid meningiomas is essential for appropriate patient management.
  • This case highlights the importance of detailed histopathological analysis for classifying meningioma subtypes.
  • Understanding these rare subtypes aids in refining diagnostic criteria and treatment strategies for meningiomas.