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Related Experiment Video

Updated: May 24, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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Published on: October 26, 2015

[Development of polaprezinc research].

¹Pharmacological Research, Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan. mineo-takei@zeria.co.jp

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan

|March 3, 2012

Summary

Polaprezinc effectively treats taste disorders caused by zinc deficiency. It restores zinc levels in the tongue and improves taste bud cell proliferation, offering a new therapeutic avenue.

Area of Science:

Biochemistry
Nutritional Science
Pharmacology

Background:

Zinc is an essential trace element vital for numerous bodily functions, including protein and DNA synthesis.
Zinc deficiency can lead to pathological conditions like growth retardation, skin issues, and taste disorders.
Polaprezinc, a zinc-L-carnosine compound, is used for gastric ulcers and is being investigated for taste disorders.

Purpose of the Study:

To investigate the pharmacological effects of polaprezinc on taste disorders induced by zinc deficiency.
To elucidate the mechanism by which polaprezinc restores taste function.

Main Methods:

Rats were fed a zinc-deficient diet to induce taste disorders.
The effects of polaprezinc administration were assessed on lingual zinc content and taste bud cell proliferation.

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Pharmacological actions were analyzed in the context of zinc deficiency.

Main Results:

Polaprezinc treatment restored reduced zinc content in the lingual epithelium of zinc-deficient rats.
Polaprezinc improved the delayed cell proliferation of taste bud cells caused by zinc deficiency.
The study identified mechanisms underlying polaprezinc's efficacy in taste disorder recovery.

Conclusions:

Polaprezinc demonstrates significant therapeutic potential for taste disorders linked to zinc deficiency.
Restoration of lingual zinc levels and enhancement of taste bud cell proliferation are key mechanisms of action.
Further research into polaprezinc's broader applications is warranted.