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Related Concept Videos

Appendicitis01:19

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

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Related Experiment Video

Updated: May 24, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Association Between Appendectomy and Clostridium difficile Infection.

Rashida Merchant1, William R Mower, Ariel Ourian

  • 1The UCLA Emergency Medicine Center, UCLA Geffen School of Medicine, Los Angeles, CA, USA.

Journal of Clinical Medicine Research
|March 3, 2012
PubMed
Summary
This summary is machine-generated.

The appendix may not protect against Clostridium difficile infection. Patients with C. difficile were less likely to have had an appendectomy, suggesting an intact appendix promotes infection.

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Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Area of Science:

  • Microbiology
  • Gastroenterology
  • Immunology

Background:

  • The appendix is theorized to harbor beneficial bacteria, potentially protecting against Clostridium difficile.
  • This study investigated if an intact appendix confers protection against C. difficile infection.

Purpose of the Study:

  • To test the hypothesis that appendectomy is more common in patients with C. difficile compared to those without.
  • To evaluate the role of the appendix in C. difficile infection.

Main Methods:

  • A cohort of 257 patients undergoing C. difficile testing were surveyed about prior appendectomy history.
  • Appendectomy rates were compared between patients who tested positive and negative for C. difficile.

Main Results:

  • The rate of prior appendectomy was lower in patients positive for C. difficile (19.9%) versus those negative (31.4%).
  • Patients testing positive for C. difficile were more likely to have an intact appendix.

Conclusions:

  • An intact appendix was associated with a higher likelihood of C. difficile infection, not protection.
  • Findings suggest the appendix may facilitate C. difficile acquisition, carriage, and disease.