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Benign orbital tumors with bone destruction in children
Jianhua Yan1, Sheng Zhou, Yongping Li
1The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong Province, The People's Republic of China. Yan2011@tom.com
Plos One
|March 3, 2012
Summary
Rare benign orbital tumors in children can cause significant bone destruction, mimicking malignant conditions. Conditions like eosinophilic granuloma, leiomyoma, and hemangioma were identified, all treatable without recurrence.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Pathology
Background:
- Orbital tumors in children can present with bone destruction, often leading to misdiagnosis as malignant.
- Distinguishing benign from malignant orbital masses pre-surgically is crucial for appropriate management.
Purpose of the Study:
- To highlight rare benign orbital tumors in pediatric patients that exhibit significant bone destruction.
- To discuss cases that were challenging to diagnose pre-surgically due to their presentation.
Main Methods:
- Retrospective review of clinical, operative, and pathological records.
- Inclusion criteria: pediatric patients with benign orbital tumors and bone destruction.
- Study period: 2000-2009 at a tertiary ophthalmic center in China.
Main Results:
- Eight pediatric patients with benign orbital tumors and bone destruction were identified.
- Diagnoses included: eosinophilic granuloma (6 cases), leiomyoma (1 case), and intraosseous hemangioma (1 case).
- All patients achieved normal vision and had no local recurrence after a mean follow-up of 32.8 months.
Conclusions:
- Benign orbital tumors, including eosinophilic granuloma, leiomyoma, and intraosseous hemangioma, can present with significant bone destruction.
- These benign entities should be considered in the differential diagnosis of pediatric orbital masses with bone erosion.
- Prompt diagnosis and appropriate management lead to favorable outcomes.
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