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Related Experiment Video

Updated: May 24, 2026

Standing Neurophysiological Assessment of Lower Extremity Muscles Post-Stroke

Standing Neurophysiological Assessment of Lower Extremity Muscles Post-Stroke

Published on: July 26, 2021

Post-stroke fatigue.

Vladimira Vuletić¹, Zeljka Lezaić, Sandra Morović

¹University Department of Neurology, Dubrava University Hospital, Zagreb, Croatia. vladimira.vuletic@kbd.hr

Acta Clinica Croatica

|March 6, 2012

Summary

Post-stroke fatigue affects nearly half of patients and is linked to anxiety and depression. Further research is needed to develop effective treatments for this common post-stroke complication.

Area of Science:

Neurology
Psychiatry
Rehabilitation Medicine

Background:

Post-stroke fatigue is a prevalent and debilitating condition impacting patient recovery and quality of life.
It is often overlooked, necessitating a deeper understanding of its prevalence and contributing factors.

Purpose of the Study:

To assess the prevalence and severity of fatigue in post-stroke patients.
To investigate the relationship between fatigue and personal/stroke-related factors, including functional status, anxiety, and depression.
To compare fatigue levels in stroke survivors with age- and sex-matched healthy controls.

Main Methods:

A study involving 35 three-month post-stroke patients and 35 healthy controls.
Fatigue was measured using the Fatigue Severity Scale (FSS) and Multidimensional Fatigue Inventory (MFI-20).

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Functional status was assessed with the Barthel index, and anxiety/depression with the Hospital Anxiety and Depression Scale (HADS).

Main Results:

Fatigue was frequent (45%) and often severe in post-stroke patients compared to controls (11%).
Stroke patients reported higher general fatigue, physical fatigue, and reduced activity.
Significant associations were found between fatigue and anxiety (P=0.01), depression (P=0.02), and global fatigue with Barthel index score (P=0.01).
Multivariate analysis indicated that anxiety and depression symptoms predict post-stroke fatigue (adjusted R2=0.556, P<0.05).

Conclusions:

Post-stroke fatigue is common and significantly associated with psychological distress and functional status.
Anxiety and depression are key predictors of post-stroke fatigue.
Further clinical trials are warranted to establish effective treatments for post-stroke fatigue.