Related Experiment Video
Updated: May 24, 2026

Postoperative Ileus Murine Model
Published on: July 12, 2024
Management of postoperative ileus
Melissa Thompson1, Barbara Magnuson
1Department of Pharmacy, University of Kentucky Hospital, 800 Rose St, H110, Lexington, KY 40536-2093, USA. mlthompson@uky.edu
Abstract:
Postoperative ileus, a temporary cessation in bowel motility, is a common and significant complication of major surgery. Consequences of postoperative ileus include increased patient discomfort, delayed time to adequate nutrition, prolonged length of stay, and increased cost to the patient and healthcare system. The traditional, multi-modal approach to the resolution of postoperative ileus includes opioid minimization, early ambulation, and early feeding. Newer medications, such as methlynaltrexone and alvimopan (which are peripherally acting mu opioid receptor antagonists), have become available and have proven beneficial for use with postoperative ileus.
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