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Related Experiment Video

Updated: May 24, 2026

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic

Claudia Benz¹, Michael R Copley, David G Kent

¹Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada.

|March 6, 2012

Summary

Adult hematopoietic stem cells (HSCs) exist in two subtypes, differing in mature cell output. The study reveals niche-dependent regulation of HSC subtypes during development and transplantation, impacting lymphoid progenitor generation.

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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Published on: May 8, 2018

Area of Science:

Hematology
Developmental Biology
Stem Cell Biology

Background:

Adult hematopoietic stem cells (HSCs) possess serial transplantability and exist as distinct subtypes.
One HSC subtype produces balanced lymphoid and myeloid cells, while another is selectively lymphoid deficient.

Purpose of the Study:

To investigate the developmental distribution and niche-dependent regulation of HSC subtypes.
To analyze the self-renewal and differentiation potential of distinct HSC subtypes.

Main Methods:

Comparative analysis of HSC subtypes in fetal liver and bone marrow.
Clonal analysis of HSC expansion and differentiation post-transplantation.

Main Results:

Both HSC subtypes are present in fetal liver, with lymphoid-deficient HSCs enriched in fetal bone marrow.
HSC subtypes exhibit variable self-renewal and occasional interconversion.
Subtypes show distinct lymphoid progenitor generation but indistinguishable multipotent and myeloid progenitor production.

Conclusions:

The bone marrow niche regulates preferential amplification of specific HSC subtypes.
HSC heterogeneity influences differentiation and expansion control, with implications for other stem cell systems.