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Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
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Mechanisms for insulin resistance: common threads and missing links

Varman T Samuel1, Gerald I Shulman

  • 1Department of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA. varman.samuel@yale.edu

Cell
|March 6, 2012
PubMed
Summary

Insulin resistance involves complex metabolic pathways, including ectopic lipid accumulation, unfolded protein response, and immune responses. These factors converge, promoting lipid metabolites in the liver and muscle, impairing insulin signaling.

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