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Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Factors Affecting Pulmonary Ventilation

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Chronic Obstructive Pulmonary Disease-II: Pathophysiology

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Asthma-II: Pathophysiology and Classification

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Asthma I: Introduction

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Updated: May 7, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 5, 2010

Asthma outcomes: pulmonary physiology.

Robert S Tepper¹, Robert S Wise, Ronina Covar

¹Indiana University, Indianapolis, Indiana, USA.

The Journal of Allergy and Clinical Immunology

|March 6, 2012

Summary

This summary is machine-generated.

Pulmonary function tests are crucial for asthma research. Spirometric outcomes like FEV1 are recommended as core measures for future clinical trials to ensure consistent comparisons.

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Published on: July 10, 2018

Area of Science:

Pulmonary physiology
Asthma research
Clinical trials

Background:

Pulmonary physiology outcomes are vital in asthma clinical research.
Standardized assessment of these outcomes is needed for cross-study comparisons.

Purpose of the Study:

To provide recommendations on pulmonary function measures as asthma outcomes.
To standardize their assessment in future asthma clinical trials and studies.

Main Methods:

A subcommittee conducted a PubMed search for validated airway response tests in asthma research.
Instruments were classified as core, supplemental, or emerging.
Findings were discussed at an NIH workshop and finalized.

Main Results:

A list of pulmonary physiology outcomes for adults and children over 6 years was created.
Outcomes were categorized into core, supplemental, and emerging.
Spirometric outcomes (FEV1, FVC, FEV1/FVC) and bronchodilator reversibility were proposed as core outcomes.

Conclusions:

Pulmonary physiology outcomes are critically important in asthma research.
Spirometric outcomes are recommended as core for all future NIH-initiated asthma clinical research.