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Protocol to Create Chronic Wounds in Diabetic Mice

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Published on: September 25, 2019

Diabetes and mucormycosis: a complex interplay.

B Rammaert¹, F Lanternier, S Poirée

¹Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Université Paris Descartes, Hôpital Necker-Enfants-Malades, Institut Imagine, AP-HP, 149, rue des Sèvres, 75743 Paris cedex 15, France.

Diabetes & Metabolism

|March 6, 2012

Summary

This summary is machine-generated.

Mucormycosis, a dangerous fungal infection, often affects diabetic patients. Early suspicion in diabetic patients with sinusitis is crucial for timely diagnosis and treatment of this invasive condition.

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Area of Science:

Infectious Diseases
Mycology
Endocrinology

Background:

Mucormycosis is a severe, invasive fungal infection.
It disproportionately affects patients with diabetes mellitus.
Underlying conditions like hematological malignancies and organ transplants increase risk.

Purpose of the Study:

To provide clinicians with comprehensive information on mucormycosis in diabetic patients.
To review the specificities, epidemiology, and pathophysiology of mucormycosis in the context of diabetes.
To highlight the importance of early diagnosis in at-risk populations.

Main Methods:

Extensive literature review.
Synthesis of existing data on mucormycosis.
Focus on clinical presentation, risk factors, and disease mechanisms in diabetic individuals.

Main Results:

Rhino-orbito-cerebral involvement is common but may present subtly.
Non-bacteriological sinusitis in diabetics warrants high suspicion for mucormycosis, even without ketoacidosis.
Diabetes is a significant risk factor for invasive fungal infections.

Conclusions:

Early recognition and diagnosis of mucormycosis are critical for improving patient outcomes.
Clinicians managing diabetic patients should maintain a low threshold for suspecting mucormycosis.
Understanding the interplay between diabetes and fungal pathogenesis is key to effective management.