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Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study

Rajkumar Rajule1, Vashti C Bryant, Hernando Lopez

  • 1Eppley Institute for Cancer Research, University of Nebraska Medical Center, Omaha, NE 68198, United States.

Bioorganic & Medicinal Chemistry
|March 6, 2012
PubMed
Summary

Researchers identified a novel quinoxaline urea analog (1h) that specifically induces Mcl-1 dependent apoptosis. This compound shows therapeutic potential, especially in combination with ABT-737 for treating refractory cancers.

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