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Could age modify the effect of genetic variants in IL6 and TNF-α genes in multiple myeloma?
Alessandro Martino1, Gabriele Buda, Valentina Maggini
1Department of Biology, Genetics division, University of Pisa, Italy. a.martino@dkfz-heidelberg.de
Abstract:
Cytokines play a central role in multiple myeloma (MM) pathogenesis thus genetic variations within cytokines coding genes could influence MM susceptibility and therapy outcome. We investigated the impact of 8 SNPs in these genes in 202 MM cases and 235 controls also evaluating their impact on therapy outcome in a subset of 91 patients. Despite the overall negative findings, we found a significant age-modified effect of IL6 and TNF-α SNPs, on MM risk and therapy outcome, respectively. Therefore, this observation suggests that genetic variation in inflammation-related genes could be an important mediator of the complex interplay between ageing and cancer.
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