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Updated: May 24, 2026
Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice
Published on: November 11, 2021
Apelin-13 microinjection into the paraventricular nucleus increased sympathetic nerve activity innervating brown
Takayuki Masaki1, Tohru Yasuda, Hironobu Yoshimatsu
1Department of Internal Medicine I, Faculty of Medicine, Oita University, Hasama, Oita 879-5593, Japan. masaki@oita-u.ac.jp
Abstract:
The aim of present study is to clarify the role of apelin in regulating energy homeostasis in brown adipose tissue (BAT). We examined the central effects of apelin-13 on the brain c-fos like immunoreactivity (c-FLI), BAT temperature and the activity of the sympathetic nerve activity innervating BAT in rats. In the hypothalamus, central infusion into the third cerebral ventricle (i3vt) of apelin-13 caused induction of c-FLI in the paraventricular nucleus (PVN) compared with the controls (PBS-treated) group. In addition, microinjection of apelin-13 into the PVN produced significant increases in BAT temperature. Furthermore, microinjection of apelin-13 treatment increased BAT sympathetic nerve activity compared with controls. We conclude that apelin-13 microinjection into PVN increases sympathetic nerve activity innervating BAT.
