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Related Concept Videos

Action Potential01:14

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...

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Related Experiment Video

Updated: May 24, 2026

In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-Neuron Resolution
06:18

In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-Neuron Resolution

Published on: November 21, 2023

Spontaneous activity in developing sensory circuits: Implications for resting state fMRI.

Matthew Colonnese1, Rustem Khazipov

  • 1INSERM, U29, INMED, Marseille 13009, France. colonnese@gwu.edu

Neuroimage
|March 6, 2012
PubMed
Summary

Immature brain

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Computational Neuroscience

Background:

  • Immature brains exhibit unique electrical activity crucial for neuronal network development.
  • Resting brain activity in neonates shares superficial similarities with adult resting-state networks.
  • The developmental origins and functional significance of neonatal resting activity remain unclear.

Purpose of the Study:

  • To review studies investigating the generative mechanisms of resting-state activity during early brain development.
  • To explore the functional and origin differences between neonatal and adult resting brain activity.
  • To propose a conservative interpretation of developmental neuroimaging studies.

Main Methods:

  • Review of recent studies on neonatal rodent and premature human infant primary sensory systems.

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Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
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Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

Related Experiment Videos

Last Updated: May 24, 2026

In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-Neuron Resolution
06:18

In Vivo Visualization of Spontaneous Activity in Neonatal Mouse Sensory Cortex at a Single-Neuron Resolution

Published on: November 21, 2023

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
10:19

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo

Published on: March 31, 2016

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
07:13

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

  • Analysis of spontaneous thalamocortical activity during early development.
  • Comparison of generative mechanisms in immature versus mature brains.

    • Main Results:

    • Neonatal resting activity, while superficially resembling adult patterns, differs fundamentally in function and origin.
    • Early spontaneous thalamocortical activity is driven by peripheral sensory generators.
    • Adult spontaneous activity is dominated by thalamocortical and cortico-cortical connections.

    Conclusions:

    • Resting-state activity in early development is generated differently and serves distinct roles (e.g., circuit formation) compared to adults (e.g., attention).
    • Developmental neuroimaging studies should cautiously interpret findings, considering age-specific generative mechanisms.
    • Current analytical methods based on adult brain patterns may misinterpret neonatal brain activity.