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Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Cyclodextrin-based nanogels for pharmaceutical and biomedical applications.

Maria D Moya-Ortega1, Carmen Alvarez-Lorenzo, Angel Concheiro

  • 1Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, Iceland.

International Journal of Pharmaceutics
|March 6, 2012
PubMed
Summary

Hydrophilic nanogels with cyclodextrin (CD) moieties offer advanced drug delivery. These CD-based nanogels enhance drug loading and controlled release for pharmaceutical applications.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Nanotechnology

Background:

  • Hydrophilic nanogels combine hydrogel and nanoparticle benefits.
  • They offer drug encapsulation, controlled release, and parenteral delivery advantages.
  • Nanoscale size provides high surface area for bioconjugation and tunable biodistribution.

Purpose of the Study:

  • To review the preparation, characterization, and applications of cyclodextrin (CD)-based nanogels.
  • To highlight the drug loading and release mechanisms facilitated by CD moieties.
  • To discuss the advantages of CD-based nanogels in pharmaceutical and biomedical fields.

Main Methods:

  • Incorporation of hydrophilic cyclodextrin (CD) moieties into nanogel polymer networks.
  • Covalent attachment of CD molecules to chemically crosslinked networks.
  • Characterization of nanogel properties and drug release profiles.

Main Results:

  • CD-based nanogels enable drug loading and release via inclusion complex formation without compromising hydrophilicity.
  • Covalent attachment of CDs enhances complexation efficiency and prevents premature drug release.
  • Nanogel size modulation allows control over biodistribution and release kinetics.

Conclusions:

  • CD-based nanogels represent a promising platform for advanced drug delivery systems.
  • Their unique properties facilitate efficient drug loading, controlled release, and targeted delivery.
  • Further research and development hold significant potential for pharmaceutical and biomedical applications.