Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

STARTER: a stand-alone reconfigurable and translational organ-on-chip platform based on modularity and open design principles.

Lab on a chip·2026
Same author

A workflow integrating organ-on-chip culture and correlative 3D light and electron microscopy for microtissue analysis.

Scientific reports·2025
Same author

Accurate Sizing of Monodisperse Microbubble Suspensions by Optical Attenuation Spectroscopy.

Ultrasound in medicine & biology·2025
Same author

Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk.

Molecular omics·2025
Same author

Organoids-on-a-chip: microfluidic technology enables culture of organoids with enhanced tissue function and potential for disease modeling.

Frontiers in bioengineering and biotechnology·2025
Same author

Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19.

Lab on a chip·2025

Related Experiment Video

Updated: May 24, 2026

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip
09:46

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Published on: February 17, 2023

Organs-on-chips: breaking the in vitro impasse.

Andries D van der Meer1, Albert van den Berg

  • 1BIOS/Lab on a Chip group, MESA+ Institute for Nanotechnology, University of Twente, The Netherlands.

Integrative Biology : Quantitative Biosciences From Nano to Macro
|March 6, 2012
PubMed
Summary
This summary is machine-generated.

Organs-on-chips offer a solution to the limitations of traditional in vitro models by recreating complex human tissues. These microengineered systems balance realism and robustness for advanced physiological research.

More Related Videos

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
08:04

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

Related Experiment Videos

Last Updated: May 24, 2026

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip
09:46

Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip

Published on: February 17, 2023

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing
08:04

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

Area of Science:

  • Biotechnology
  • Tissue Engineering
  • Physiology

Background:

  • In vitro models are crucial for studying human physiology and disease.
  • Current models face a trade-off between biological realism and research robustness.
  • This limitation creates an impasse in developing more accurate in vitro systems.

Purpose of the Study:

  • To define the "in vitro impasse" in biological modeling.
  • To explore organs-on-chips as a solution to overcome this impasse.
  • To outline the future direction of organ-on-chip technology.

Main Methods:

  • Reviewing the limitations of traditional in vitro models.
  • Analyzing the design principles of organs-on-chips.
  • Discussing the integration of engineering and biological components.

Main Results:

  • Organs-on-chips integrate microengineering with cell culture for physiological relevance.
  • These models offer controlled environments, enabling parallelized and high-throughput studies.
  • They address the realism vs. robustness trade-off inherent in simpler models.

Conclusions:

  • Organs-on-chips represent a significant advancement in in vitro modeling.
  • They have the potential to revolutionize physiological and pathological research.
  • Future development requires focus on design, technological integration, and user needs.