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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

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Related Experiment Video

Updated: May 24, 2026

Preparing a 68Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis
07:48

Preparing a 68Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis

Published on: January 7, 2019

Radiolabelled RGD peptides for imaging and therapy.

F C Gaertner1, H Kessler, H-J Wester

  • 1Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, 81675 Munich, Germany. florian.gaertner@tum.de

European Journal of Nuclear Medicine and Molecular Imaging
|March 6, 2012
PubMed
Summary
This summary is machine-generated.

Radiolabeled RGD peptides offer a promising non-invasive method for imaging angiogenesis, particularly for assessing targeted antiangiogenic therapies. This approach visualizes integrin alpha-v-beta-3 expression, with potential for future radionuclide therapy applications.

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Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue

Published on: August 17, 2016

Area of Science:

  • Molecular imaging
  • Oncology
  • Radiopharmaceutical science

Background:

  • Angiogenesis imaging is crucial for evaluating antiangiogenic therapies like bevacizumab.
  • Non-invasive assessment of angiogenic activity aids in treatment response evaluation.
  • Integrin α(v)β(3) is a key molecular marker of the angiogenic cascade.

Purpose of the Study:

  • To review current data on imaging integrin α(v)β(3) expression using radiolabeled RGD peptides.
  • To focus on tracers currently in clinical use for angiogenesis imaging.
  • To present future perspectives on clinical applications of radiolabeled RGD peptides, including radionuclide therapy.

Main Methods:

  • Review of current literature on radiolabeled RGD peptides for imaging integrin α(v)β(3).
  • Focus on tracers that have achieved clinical translation.
  • Analysis of data related to clinical use and potential therapeutic applications.

Main Results:

  • Radiolabeled peptides targeting integrin α(v)β(3) represent a clinically validated approach for angiogenesis imaging.
  • Several RGD peptide-based tracers are in clinical use for molecular imaging.
  • The review summarizes existing clinical data and ongoing research.

Conclusions:

  • Radiolabeled RGD peptides are a valuable tool for non-invasive angiogenesis imaging and therapy response assessment.
  • Future applications may include radionuclide therapy for targeting α(v)β(3)-expressing tumors.
  • Continued research will expand the clinical utility of these targeted radiotracers.