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Updated: May 24, 2026
09:15
Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
Published on: May 7, 2019
[Apheresis in ABO-incompatible kidney transplant]
Enzo Capocasale1, Maurizio Iaria, Maria Sassi
1Azienda Ospedaliero-Universitaria di Parma, Parma, Italy. ecapocasale@ao.pr.it
Summary
Living donor kidney transplantation overcomes ABO incompatibility using desensitization protocols. Selective immunoadsorption is a safe and effective method for ABO-incompatible kidney transplants, showing good long-term graft survival.
Area of Science:
- Nephrology
- Immunology
- Transplantation
Context:
- End-stage renal disease (ESRD) patients often face kidney transplant rejection due to immunological barriers like ABO incompatibility.
- Approximately 20-30% of potential living kidney donors are rejected, limiting transplantation options.
Purpose:
- To evaluate the efficacy and safety of desensitization protocols, specifically selective immunoadsorption, in ABO-incompatible kidney transplantation.
- To overcome antibody barriers and prevent antibody rebound post-transplantation.
Summary:
- Newer desensitization protocols utilize therapeutic apheresis and immunosuppressive drugs to manage antibody barriers in ABO-incompatible kidney transplants.
- Selective immunoadsorption is highlighted as a safer and more effective apheresis modality than plasmapheresis, minimizing plasma and coagulation abnormalities.
- Long-term patient and graft survival rates in ABO-incompatible transplants are comparable to ABO-compatible transplants.
Impact:
- Selective immunoadsorption demonstrates high efficacy and safety in ABO-incompatible kidney transplantation, as evidenced by successful cases with no acute rejection and well-functioning grafts.
- Further research is needed to define optimal desensitization protocols, antibody titer limits, and measurement assays for ABO-incompatible kidney transplantation.
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