[Apheresis in children: procedures and outcome]

Area of Science:

• Pediatric Nephrology
• Immunology
• Hematology

Context:

• Apheresis procedures are increasingly utilized in pediatric care for various conditions.
• Adapting adult apheresis techniques for children presents unique challenges.
• Previous studies explored initial experiences and technical adaptations.

Purpose:

• To present data from a larger cohort of pediatric patients where apheresis was the primary treatment.
• To evaluate the efficacy and safety of apheresis in children with renal and extrarenal diseases.
• To assess the feasibility of apheresis in younger and lower-weight children.

Summary:

• Ninety-three children with renal and/or extrarenal diseases underwent LDL apheresis, protein A immunoadsorption, or plasma exchange.
• Renal diseases and immunological disorders were the most common indications.
• Hemolytic uremic syndrome (HUS) is now primarily treated with apheresis only in atypical forms.
• Apheresis was successfully performed in younger children, demonstrating low weight is not a contraindication.

Impact:

• Apheresis demonstrates a low complication rate and satisfactory clinical results in pediatric patients.
• The findings support the expanded use of apheresis as a viable treatment option for children.
• Technical advancements enhance the feasibility and effectiveness of pediatric apheresis procedures.