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A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

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Published on: January 22, 2016

The effect of d-methamphetamine on simulated driving performance.

Beata Y Silber¹, Rodney J Croft, Luke A Downey

¹Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Victoria, Australia.

Human Psychopharmacology

|March 6, 2012

Summary

This study found that a moderate dose of d-methamphetamine did not significantly impair simulated driving performance. However, drivers under the influence drove slower in emergencies and showed a trend towards running more red lights.

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Area of Science:

Neuroscience
Forensic Science
Psychopharmacology

Background:

Methamphetamine is a commonly abused drug by drivers, yet its precise impact on driving behavior remains under-researched.
Epidemiological data suggest a link between methamphetamine use and driving impairment, evidenced by its prevalence in impaired driving incidents.

Purpose of the Study:

To investigate the effects of a controlled dose of d-methamphetamine on simulated driving performance and behavior.
To compare driving performance under d-methamphetamine versus placebo conditions in recreational stimulant users.

Main Methods:

A double-blind, placebo-controlled study involving 20 healthy recreational stimulant users (21-32 years old).
Participants underwent two sessions, receiving either 0.42 mg/kg oral d-methamphetamine or a placebo.
Simulated driving performance was assessed 2.5 hours post-administration.

Main Results:

Overall simulated driving performance was not significantly impaired by d-methamphetamine (0.42 mg/kg).
Participants on d-methamphetamine drove slower during simulated emergency situations (p < 0.05).
A trend indicated more red light infringements in the d-methamphetamine group (p = 0.11), with both groups exceeding the speed limit in emergencies.

Conclusions:

The tested dose of d-methamphetamine did not impair driving performance as much as epidemiological data might suggest.
Further research is needed to explore the effects of varying methamphetamine doses and combinations with other substances on driving.
The findings highlight a potential discrepancy between controlled study results and real-world driving impairment linked to methamphetamine use.