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Updated: May 24, 2026

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers
15:42

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers

Published on: March 6, 2009

MHC class II tetramers

Gerald T Nepom1

  • 1Benaroya Research Institute, Seattle, WA 98101, USA. nepom@benaroyaresearch.org

Journal of Immunology (Baltimore, Md. : 1950)
|March 6, 2012
PubMed

MHC class II tetramers have emerged as an important tool for characterization of the specificity and phenotype of CD4 T cell immune responses, useful in a large variety of disease and vaccine studies. Issues of specific T cell frequency, biodistribution, and avidity, coupled with the large genetic diversity of potential class II restriction elements, require targeted experimental design. Translational opportunities for immune disease monitoring are driving the rapid development of HLA class II tetramer use in clinical applications, together with innovations in tetramer production and epitope discovery.

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