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Related Experiment Video

Updated: May 24, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025

Targeting fatigue in stroke patients.

Andrew W Barritt1, David G Smithard

  • 1Division of Medicine, Royal Sussex County Hospital, Brighton, East Sussex BN2 5BE, UK.

ISRN Neurology
|March 6, 2012
PubMed
Summary

Post-stroke fatigue is common and linked to poorer outcomes. Inflammatory pathways triggered by the stroke may cause this fatigue, offering potential therapeutic targets for management.

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Area of Science:

  • Neurology
  • Neuroscience
  • Immunology

Background:

  • Fatigue is a prevalent symptom in both acute and chronic stroke recovery.
  • It frequently co-occurs with mood and sleep issues but can also manifest independently.
  • This symptom is associated with diminished long-term recovery outcomes, necessitating a deeper understanding of its origins.

Purpose of the Study:

  • To investigate the underlying mechanisms of post-stroke fatigue.
  • To explore the role of inflammatory processes in the development of fatigue after stroke.
  • To identify potential therapeutic targets for managing post-stroke fatigue.

Main Methods:

  • Review of existing evidence on post-stroke fatigue.
  • Analysis of the role of inflammatory cascades and cytokine signaling in stroke recovery.
  • Examination of pathways linking brain injury to systemic symptoms.

Main Results:

  • Convincing evidence supports the role of inflammatory cascades initiated by the stroke infarct in promoting fatigue.
  • Cytokine signaling pathways are implicated as key mediators of this fatigue.
  • These inflammatory mechanisms offer plausible explanations for the occurrence of fatigue.

Conclusions:

  • Inflammatory processes triggered by stroke play a significant role in the development of fatigue.
  • Understanding these cytokine-mediated pathways is crucial for developing effective fatigue management strategies.
  • Targeting inflammatory pathways presents a promising avenue for therapeutic intervention in post-stroke fatigue.

Related Experiment Videos

Last Updated: May 24, 2026

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
08:53

Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke

Published on: June 6, 2025