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Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination
15:25

Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination

Published on: July 4, 2007

Profile of dengue patients admitted to a tertiary care hospital in Mumbai

Rajesh Joshi1, Vikram Baid

  • 1Department of Pediatrics, B. J. Wadia Hospital for Children, Parel, Mumbai, India.

The Turkish Journal of Pediatrics
|March 7, 2012
PubMed

Insights

Dengue fever in children presents with fever, vomiting, and bleeding. Key indicators include low platelets and plasma leakage, with certain lab values predicting severity.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Dengue is a growing mosquito-borne arboviral infection concern in India, with rising endemicity in Mumbai.
  • This study focuses on the clinical profile and outcomes of dengue infection in children admitted to a Mumbai teaching hospital.

Purpose of the Study:

  • To retrospectively analyze the clinical and laboratory findings in children with dengue infection.
  • To identify predictors of dengue severity and understand treatment outcomes.

Main Methods:

  • Retrospective study of 57 children with confirmed dengue infection (IgM antibodies by ELISA).
  • Data collected included clinical signs, laboratory results, and patient outcomes over a 12-month period in 2008.

Main Results:

  • Common symptoms: fever (100%), hepatomegaly (66.6%), vomiting (40.3%), bleeding (38.5%).
  • Frequent lab findings: thrombocytopenia (96.5%), elevated liver enzymes (59.6%), hypoalbuminemia (50.8%), hyponatremia (40.3%), deranged PT/PTT (33.3%).
  • Plasma leakage (ascites, pleural effusion) observed in 15.7% and 31.5% respectively; PT/PTT, serum sodium, albumin, and WBC counts predicted severity.

Conclusions:

  • Fever, hemorrhagic manifestations, hepatomegaly, thrombocytopenia, and plasma leakage signs suggest dengue in children.
  • Dengue shock syndrome requires intensive supportive care and prolonged recovery.
  • Mortality was 3.5%, with specific laboratory parameters indicating disease severity.

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