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Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: May 24, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

Differences between veteran suicides with and without psychiatric symptoms.

Peter C Britton¹, Mark A Ilgen, Marcia Valenstein

¹VISN 2 Center of Excellence for Suicide Prevention, Department of Veteran Affairs Medical Center, Canandaigua, NY 14424, USA. peter.britton@va.gov

American Journal of Public Health

|March 7, 2012

Summary

Veterans with psychiatric symptoms faced higher suicide risks and died sooner after VHA visits. Tailored prevention is crucial for all veterans, including those without identified psychiatric conditions.

Related Experiment Videos

Last Updated: May 24, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

Area of Science:

Psychiatry
Public Health
Veterans Affairs

Background:

Suicide is a significant concern among veterans.
Understanding risk factors is crucial for effective prevention strategies within the Veterans Health Administration (VHA).

Purpose of the Study:

To examine suicide patterns in two VHA geographic areas over seven years.
To compare veterans with and without documented psychiatric symptoms regarding suicide risk and outcomes.

Main Methods:

Analysis of 423 suicides within the VHA.
Detailed chart reviews of 381 veterans with VHA visits in their last year of life.
Comparison of groups based on psychiatric symptoms, suicidal behaviors, somatic symptoms, stressors, and time to death post-visit.

Main Results:

Veterans with psychiatric symptoms were more likely to receive suicide risk assessments, report suicidal ideation and plans, and experience sleep problems, pain, and stressors.
These veterans also had a higher likelihood of dying within 60 days of their last VHA visit.
A distinct group of veterans without documented psychiatric symptoms also exhibited significant suicide risk.

Conclusions:

Two distinct groups of veterans at risk for suicide exist within the VHA.
Tailored suicide prevention strategies are essential for both groups.
Prevention approaches must consider veterans without identified psychiatric symptoms.