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Updated: May 24, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
Published on: August 16, 2016
Heterogeneity of multiple-pore membranes investigated with ion conductance microscopy
Yi Zhou1, Chiao-Chen Chen, Lane A Baker
1Department of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Abstract:
Heterogeneous conductance of individual pores on a porous membrane was studied with a four-electrode scanning ion conductance microscope (SICM). Application of a potential difference across the membrane resulted in migration of ions through nanopores, where subsequent conductance changes were measured by a nanopipet positioned above the nanopore as a change in pipet current. Current responses of single-pore membranes and individual pores within a multipore membrane were examined and demonstrated variations in ion current rectification (ICR) ratios due to the small differences in pore geometries.
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