Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses, temperature changes,...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Active Insulin Time and Glycemic Targets on Automatic Correction Bolus Delivery.

Journal of diabetes science and technology·2026
Same author

The Automatic Correction Boluses in an Advanced Hybrid Closed-Loop System: Algorithm Performance and Clinical Implications.

Journal of diabetes science and technology·2026
Same author

Effect of daily insulin delivery variability on glycemic outcomes in patients with type 1 diabetes mellitus using an automated insulin delivery system.

Diabetes research and clinical practice·2025
Same author

Impact of automated insulin delivery (AID) systems on quality of life (QoL): Validation of the AID-QoL questionnaire.

Journal of diabetes and its complications·2025
Same author

Primary signet ring cell carcinoma of the lung in patient with superior vena cava syndrome and lymphangitic carcinomatosis: a case report.

Internal and emergency medicine·2025
Same author

Oxidative Status, Iron Plasma Levels in Venous Thrombosis Patients.

Antioxidants (Basel, Switzerland)·2024

Related Experiment Video

Updated: May 24, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
08:16

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

Inflammation in peripheral arterial disease (PAD).

Salvatore Santo Signorelli1, Massimiliano Anzaldi, Valerio Fiore

  • 1Department of Internal Medicine and Systemic Disease, School of Medicine, University of Catania, Italy. ssignore@unict.it

Current Pharmaceutical Design
|March 7, 2012
PubMed
Summary

Inflammation is closely linked to peripheral arterial disease (PAD). Biomarkers can help identify PAD risks and monitor treatment effectiveness, highlighting the importance of combating inflammation in PAD patients.

More Related Videos

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

Related Experiment Videos

Last Updated: May 24, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
08:16

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
13:48

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound

Published on: April 21, 2023

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Biomarker Research

Background:

  • Peripheral arterial disease (PAD) is prevalent in individuals over 55.
  • A strong association exists between inflammation and PAD progression.
  • Inflammatory biomarkers are increasingly studied for their role in PAD.

Purpose of the Study:

  • To review the critical role of biomarkers in PAD pathophysiology.
  • To highlight the potential of biomarkers in screening individuals at risk for PAD.
  • To emphasize the significance of targeting inflammation (phlogosis) in managing atherosclerotic diseases like PAD.

Main Methods:

  • Literature review focusing on inflammatory biomarkers and PAD.
  • Analysis of research on biomarker efficiency in monitoring PAD treatments.
  • Synthesis of current understanding regarding inflammation's role in PAD.

Main Results:

  • Biomarkers are integral to understanding PAD pathophysiology.
  • Screening for specific biomarkers can identify individuals with pathophysiological signs of PAD.
  • Inflammation is a key factor in the development and progression of PAD.

Conclusions:

  • Biomarkers are crucial for PAD assessment and management.
  • Targeting inflammation is essential for reducing the prevalence and consequences of PAD.
  • Further research is needed to combat phlogosis, particularly in PAD patients.