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Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

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Isolation of Mouse Lung Dendritic Cells
09:04

Isolation of Mouse Lung Dendritic Cells

Published on: November 22, 2011

Dendritic cells in pathogenesis of COPD.

Masoumeh Ezzati Givi1, Frank A Redegeld, Gert Folkerts

  • 1Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.

Current Pharmaceutical Design
|March 7, 2012
PubMed
Summary

Dendritic cells (DCs) play a role in Chronic Obstructive Pulmonary Disease (COPD) pathogenesis. Cigarette smoke (CS) alters DC numbers and prompts chemokine release, contributing to COPD development.

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Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
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Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

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Isolation of Mouse Lung Dendritic Cells
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Human Lung Dendritic Cells: Spatial Distribution and Phenotypic Identification in Endobronchial Biopsies Using Immunohistochemistry and Flow Cytometry
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Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation
07:52

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

Area of Science:

  • Immunology
  • Pulmonology
  • Cell Biology

Background:

  • Chronic Obstructive Pulmonary Disease (COPD) affects 200 million globally, with rising incidence in developing nations.
  • COPD pathogenesis involves inflammatory immune responses to inhaled toxins, primarily from cigarette smoking.
  • Inflammation leads to tissue repair, mucus overproduction, and lung destruction in COPD.

Purpose of the Study:

  • To review the role of dendritic cells (DCs) in COPD pathogenesis.
  • To explore the mediators involved in DC function during COPD.
  • To discuss DC activation and signaling in response to cigarette smoke (CS).

Main Methods:

  • Literature review focusing on dendritic cells in COPD.
  • Analysis of immune cell involvement in COPD airways.
  • Examination of cigarette smoke's effect on dendritic cells.

Main Results:

  • Dendritic cells (DCs) are present in inflamed COPD airways.
  • DC numbers are altered in smokers and COPD patients.
  • Cigarette smoke (CS) induces chemokine release from DCs, implicating them in COPD pathogenesis.

Conclusions:

  • Dendritic cells (DCs) are implicated in the inflammatory processes of COPD.
  • Understanding DC signaling in response to cigarette smoke (CS) is crucial for COPD research.
  • Further investigation into DCs' contribution to COPD pathogenesis is warranted.