Related Experiment Video
Updated: May 24, 2026
Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
Published on: February 18, 2016
Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice
Jaqueline Kalleian Eserian1, Vânia D'Almeida, Monica Levy Andersen
1Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Objective:
The objective of the present study was to assess whether the administration of polyunsaturated fatty acids (PUFAs) would lead to alterations in cocaine-conditioned place preference by correlating behavioral data and plasma levels of PUFAs.
Methods:
Five groups of C57Bl/6J mice received a linseed oil supplement or a control solution for 19 days and were conditioned to cocaine.
Results:
PUFAs did not exert a protective effect against cocaine-conditioned place-preference behavior, although there were significant differences in the levels of eicosapentaenoic acid (EPA) and linoleic acid among the groups tested. Higher doses of PUFAs might be necessary to induce a change in the plasma level of EPA in cocaine-conditioned mice.
Discussion:
PUFAs had no effect on cocaine-conditioned place preference.
