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Corelationship between matrix metalloproteinase 2 and 9 expression and severity of chronic rhinosinusitis with nasal
Ling-Feng Wang1, Chen-Yu Chien, Feng-Yu Chiang
1Department of Otolaryngology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Background:
Matrix metalloproteinase (MMP) is involved in the remodeling process of inflammatory airway diseases and is correlated with the severity of asthma. We hypothesized that MMP was associated with the severity of chronic rhinosinusitis with nasal polyps (CRSwNPs). We also investigated the effect of allergy on the expression of MMP in the polyp.
Methods:
The expression of MMP-2 and -9 was investigated in recurrent nasal polyps of 30 patients and in nonrecurrent nasal polyps of 31 patients undergoing endoscopic sinus surgery. These expressions were then compared with those in control nasal mucosal samples obtained from 32 patients with chronic hypertrophic rhinitis. Demographic data, Lund-Mackay (LM) score, polyp grade, and allergy status were obtained for all patients. Tissue samples were assessed via immunohistochemistry.
Results:
MMP-2 and -9 were constantly expressed in recurrent NPs, primary NPs, and control nasal mucosa. The expression of MMP-9 was significantly enhanced in glands and MMP-2 positivity was significantly increased in surface epithelium for patients with NPs when compared with control nasal mucosa. The expression of MMP-9 and -2 was not correlated with polyp grade and LM score. Allergic status is an independent factor in the expression of MMP-2 and -9.
Conclusion:
These results suggested up-regulation of MMP-9, and MMP-2 in gland and surface epithelium, respectively, were characteristic of NPs. Therefore, patients with allergy will exhibit greater MMP-2 and -9 positivity. However, the MMP-2 and -9 expression intensity was not correlated with the severity of CRS with nasal polyposis.
Insights
Matrix metalloproteinase (MMP)-2 and MMP-9 are elevated in nasal polyps, particularly in patients with allergies. However, their levels do not correlate with disease severity in chronic rhinosinusitis with nasal polyps.
Area of Science:
- Immunology
- Otorhinolaryngology
- Pathology
Background:
- Matrix metalloproteinases (MMPs) play a role in airway inflammation and disease severity.
- MMP involvement in chronic rhinosinusitis with nasal polyps (CRSwNPs) and the impact of allergies on MMP expression remain unclear.
Purpose of the Study:
- To investigate the association between MMP-2 and MMP-9 expression and the severity of CRSwNPs.
- To determine the influence of allergic status on MMP expression in nasal polyps.
Main Methods:
- Immunohistochemistry was used to assess MMP-2 and MMP-9 expression in nasal polyps from 61 patients and control mucosa from 32 patients.
- Demographic data, Lund-Mackay scores, polyp grade, and allergy status were collected.
Main Results:
- MMP-2 and MMP-9 were consistently expressed in nasal polyps and control mucosa.
- Significantly enhanced MMP-9 expression in glands and MMP-2 in surface epithelium was observed in patients with nasal polyps compared to controls.
- Allergic status was identified as an independent factor influencing MMP-2 and MMP-9 expression.
Conclusions:
- Up-regulation of MMP-9 in glands and MMP-2 in surface epithelium are characteristic of nasal polyps.
- Allergic patients exhibit greater MMP-2 and MMP-9 positivity.
- MMP expression intensity did not correlate with the severity of CRSwNPs.
