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Updated: May 24, 2026
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
Aspirin-sensitive asthma and upper airway diseases
Jinny E Chang1, William Chin, Ronald Simon
1Scripps Clinic, 3811 Valley Center Drive, San Diego, CA 92126, USA. Chang.Jinny@scrippshealth.org
American Journal of Rhinology & Allergy
|March 7, 2012
Summary
Aspirin exacerbated respiratory disease (AERD) involves nasal polyposis, rhinosinusitis, asthma, and aspirin sensitivity. Successful aspirin desensitization can lead to tolerance and improved clinical outcomes for AERD patients.
Area of Science:
- Allergy and Immunology
- Respiratory Medicine
- Pharmacology
Background:
- Aspirin exacerbated respiratory disease (AERD) is a clinical triad of asthma, nasal polyposis, and aspirin sensitivity.
- It presents a significant challenge in respiratory medicine due to its complex symptomatology.
Purpose of the Study:
- To provide a comprehensive guide on diagnosing and treating AERD.
- To detail the procedures for aspirin (ASA) challenge and desensitization.
- To outline the benefits of ASA desensitization and appropriate treatment dosages.
Main Methods:
- Diagnosis criteria for AERD are established through a literature review.
- Desensitization protocols, including oral ASA challenge and combined intranasal ketorolac and oral ASA challenge, are described.
- Evidence-based treatment approaches are synthesized.
Main Results:
- A multidimensional treatment approach is necessary for AERD.
- Successful ASA desensitization enables ASA tolerance in all patients.
- Select patients experience improved clinical markers, including reduced corticosteroid use.
Conclusions:
- ASA desensitization is a key therapeutic strategy for AERD.
- This approach can lead to significant clinical improvements and enhanced quality of life.
- Further research into optimal dosing and long-term outcomes is warranted.
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