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Increased circulating concentrations of bioactive PTH 1-84 in patients with heart failure

D Gruson1, T Lepoutre, S A Ahn

  • 1Pôle de recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Brussels, Belgium. damien.gruson@uclouvain.be

Journal of Endocrinological Investigation
|March 7, 2012
PubMed

Insights

Circulating parathyroid hormone (PTH) 1-84 levels are elevated in heart failure (HF) patients. Higher PTH 1-84 levels correlate with HF severity and biomarkers indicating disease worsening.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biomarkers

Background:

  • Parathyroid hormone (PTH) is linked to left ventricular hypertrophy.
  • Elevated PTH levels are associated with poor prognosis in heart failure (HF) patients.

Purpose of the Study:

  • To measure bioactive PTH 1-84 levels in HF patients using a third-generation assay.
  • To assess the association between PTH 1-84 levels and HF disease severity.
  • To determine the relationship between PTH 1-84 and HF worsening biomarkers.

Main Methods:

  • PTH 1-84 concentrations were measured in 76 HF patients and 49 healthy volunteers.
  • Circulating levels of Nt-proANP, BNP, Nt-proBNP, proBNP, and Big ET-1 were also quantified.

Main Results:

  • HF patients exhibited significantly higher PTH 1-84 levels compared to controls.
  • PTH 1-84 levels increased with New York Heart Association functional classes.
  • PTH 1-84 concentrations showed significant correlations with Nt-proANP, BNP, Nt-proBNP, proBNP, and Big ET-1.

Conclusions:

  • Bioactive PTH 1-84 levels are significantly elevated in HF patients.
  • Circulating PTH concentrations are related to HF severity and established biomarkers of disease progression.
Abstract

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