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Updated: May 24, 2026

07:54
Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
Published on: August 19, 2014
[Prognostic value of P53 aberrations in diffuse large B-cell lymphoma]
Jing-Tao Lu1, Ling Cen, Min Zhou
1Department of Hematology and Oncology, Nanjing Medical University, Changzhou, Jiangsu Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|March 7, 2012
Summary
P53 gene aberrations are common in diffuse large B-cell lymphoma (DLBCL). Detecting P53 abnormalities can help predict patient prognosis and guide treatment decisions.
Area of Science:
- Oncology
- Genetics
- Biochemistry
Context:
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
- The role of P53 gene and protein expression in DLBCL prognosis requires further elucidation.
Purpose:
- To investigate P53 gene aberrations and serum P53 protein levels in DLBCL patients.
- To determine the prognostic value of P53 abnormalities in DLBCL.
Summary:
- P53 gene deletion was found in 21 of 50 DLBCL cases.
- Serum P53 protein levels were elevated in DLBCL patients compared to controls.
- Abnormal P53 expression (gene deletion and high serum protein) correlated with poorer prognosis.
Impact:
- Abnormal P53 serves as an independent prognostic factor for DLBCL.
- Early detection of P53 aberrations can aid in accurate prognosis determination.
- This study highlights P53 as a potential therapeutic target in DLBCL.

