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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Autocrine Signaling01:01

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
Autocrine Signaling01:01

Autocrine Signaling

Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...

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Related Experiment Video

Updated: May 24, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

Hedgehog signaling.

Siu Wah Choy1, Shuk Han Cheng

  • 1Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong, China.

Vitamins and Hormones
|March 7, 2012
PubMed
Summary
This summary is machine-generated.

Sonic hedgehog (Shh) is crucial for vertebrate organogenesis and retinal development. Recent findings reveal a novel transcriptional cascade regulating Shh during vertebrate retinogenesis.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Neuroscience

Background:

  • The hedgehog (hh) gene, initially discovered in Drosophila, is vital for embryonic development.
  • The hedgehog signaling pathway, particularly sonic hedgehog (Shh), plays a critical role in vertebrate organogenesis and brain development.
  • Previous research highlights Shh's importance in retinal development and neurogenesis.

Purpose of the Study:

  • To elucidate the signaling mechanisms of sonic hedgehog (Shh) in vertebrate eye development.
  • To explore the role of Shh in retinogenesis.
  • To present a novel finding in the regulation of Shh during vertebrate retinal development.

Main Methods:

  • Review of existing literature on hedgehog signaling and vertebrate eye development.
  • Analysis of genetic programs controlling Shh expression.
  • Investigation of a novel transcriptional cascade involving atonal and Iroquois genes.

Main Results:

  • Sonic hedgehog (Shh) is a key ligand in the hedgehog signaling pathway, essential for vertebrate organogenesis.
  • Shh regulates neurogenesis waves in the animal retina.
  • A novel transcriptional cascade involving atonal and Iroquois genes has been identified in regulating Shh during vertebrate retinogenesis.

Conclusions:

  • Sonic hedgehog (Shh) is indispensable for vertebrate eye development and retinogenesis.
  • Understanding the genetic regulation of Shh is crucial for comprehending retinal development.
  • The newly discovered transcriptional cascade offers new insights into the molecular mechanisms of retinogenesis.