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Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
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Bioactive phenolic amides from Celtis africana.

Areej Mohammad Al-Taweel1, Shagufta Perveen, Azza Muhammed El-Shafae

  • 1Department of Pharmacogonosy, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Molecules (Basel, Switzerland)
|March 7, 2012
PubMed
Summary

Nine compounds were isolated from Celtis africana. Compounds 1-3 demonstrated significant antioxidant and anti-inflammatory effects, with moderate acetylcholinesterase enzyme inhibition.

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Area of Science:

  • Phytochemistry
  • Pharmacology

Background:

  • Celtis africana is a plant species with potential medicinal properties.
  • Isolation and characterization of its chemical constituents are crucial for understanding its bioactivity.

Purpose of the Study:

  • To isolate and identify novel compounds from Celtis africana.
  • To evaluate the antioxidant, anti-inflammatory, and acetylcholinesterase inhibitory activities of the isolated compounds.

Main Methods:

  • Isolation of nine compounds using spectroscopic techniques.
  • Screening for biological activities including antioxidant, anti-inflammatory, and enzyme inhibition assays.

Main Results:

  • Nine compounds, including three N-acyltyramines (1-3), fatty acids (4-6), and triterpenoids (7-9), were identified.
  • Compounds 1-3 exhibited significant antioxidant and anti-inflammatory properties.
  • Compounds 1-3 displayed weak to moderate acetylcholinesterase enzyme inhibition.

Conclusions:

  • Celtis africana is a source of bioactive compounds with potential therapeutic applications.
  • The N-acyltyramine derivatives show promising antioxidant and anti-inflammatory activities.