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Updated: Feb 22, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Selective arterial embolization of giant renal tuberous sclerosis
Valentina De Pasquale1, Gianluigi Natali, Piergiorgio Falappa
1Division of Pediatric Urology, Department of Nephrology-Urology, "Bambino Gesù" Children's Hospital IRCCS, Piazza S. Onofrio, 4-00165 Rome, Italy.
Abstract:
Different minimally invasive methods have been proposed to treat renal manifestation of tuberous sclerosis complex (TSC), in order to preserve kidney parenchyma and avoid nephrectomy. The case of a boy with bleeding giant angiomyolipoma treated by selective arterial embolization is discussed. The extensive renal lesions resulted significantly decreased, with resolution of arterial hypertension and abdominal symptoms. Differential renal function increased from 26.6% to 32.6%. Renal involvement in TSC requires careful parenchymal-sparing procedures. Selective embolization of the main renal lesions should be considered as first line therapy.

