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Updated: May 24, 2026

Analysis of the c-KIT Ligand Promoter Using Chromatin Immunoprecipitation
Published on: June 27, 2017
c-Kit proto-oncogene expression in endometrial hyperplasia and endometrial cancer
Ercan Yilmaz1, Onder Celik, Yavuz Simsek
1Department of Obstetrics and Gynecology, Inonu University School of Medicine, Malatya, Turkey. ercanyilmazgyn@yahoo.com
Purpose:
To evaluate the expression of c-kit (CD117) in endometrial hyperplasia and endometrial cancer.
Methods:
Expression of c-kit in 10 normal endometrium, 18 simple endometrial hyperplasia, 16 complex endometrial hyperplasia (10 cases with atypia and 6 cases without atypia), and 6 endometrial cancer were investigated by immunohistochemistry.
Results:
c-Kit expression decreased as the lesion progressed to endometrial cancer. Immunostaining was mostly focal and weak in the normal endometrium and was mostly diffuse and strong in the simple and complex endometrial hyperplasia.
Conclusions:
Simple and complex hyperplastic endometrial tissues express diffuse cytoplasmic staining for c-kit and the expression decreases with the progression of the lesion.
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