Related Experiment Video
Updated: May 24, 2026

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
Published on: January 2, 2012
Brain cortical thickness in ADHD: age, sex, and clinical correlations
Luis Guillermo Almeida Montes1, Hugo Prado Alcántara, Reyna Beatriz Martínez García
11Centro Estatal de Salud Mental, Querétaro, México.
Objective:
Longitudinal magnetic resonance imaging (MRI) studies have shown reduced cortical thickness (CT) in individuals with ADHD, but this abnormality disappears with age, suggesting developmental delay. However, cross-sectional MRI studies have shown reduced CT, suggesting abnormal development. The aim of this study was to compare whole-brain CT in male and female children, adolescents, and adults with ADHD with whole-brain CT in matched control participants.
Method:
MRI scans were performed on ADHD and control participants.
Results:
CT data revealed differences in right hemisphere (RH) only. Reduced CT was observed predominantly in the frontoparietal region. However, increased CT was observed predominantly in the occipital lobe. The CT differences were correlated with severity of ADHD. Analysis of sex differences revealed that location, number, and magnitude of CT differences were different between males and females in each age group.
Conclusion:
These data support the hypothesis that anatomical abnormalities in ADHD represent abnormal development rather than developmental delay.
More Related Videos
10:02Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
Published on: March 12, 2020
13:09Using Brain Activation (nir-HEG/Q-EEG) and Execution Measures (CPTs) in a ADHD Assessment Protocol
Published on: April 1, 2018
Related Concept Videos
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Biological Influences on Intelligence
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...