Related Experiment Video

Updated: May 24, 2026

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
09:16

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation

Syed A Ali1, Jason R Dobson, Jane B Lian

  • 1Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655, USA.

Journal of Cell Science
|March 7, 2012
PubMed
Summary

RUNX2 recruits HDAC1 to suppress rRNA transcription in bone cells. Depleting HDAC1 relieves this repression, boosting cell proliferation and protein synthesis.

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