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The Importance of H-FABP in Determining the Severity of Carbon Monoxide Poisoning

Ramazan Koylu1, Basar Cander, Zerrin Defne Dundar

  • 1Konya Training and Research Hospital, Emergency Department, Konya, Turkey.

Journal of Clinical Medicine Research
|March 7, 2012
PubMed

Insights

Heart-type fatty acid binding protein (H-FABP) effectively identifies early myocardial damage in carbon monoxide (CO) poisoning patients. Elevated H-FABP levels correlate with wall motion abnormalities, aiding in assessing poisoning severity.

Area of Science:

  • Cardiology
  • Toxicology
  • Emergency Medicine

Background:

  • Carbon monoxide (CO) poisoning is a significant public health concern, often leading to myocardial injury.
  • Assessing cardiac damage in CO poisoning patients presenting to the emergency department requires sensitive biomarkers.
  • Heart-type fatty acid binding protein (H-FABP) is a potential indicator of acute cardiac stress.

Purpose of the Study:

  • To evaluate the utility of H-FABP in detecting myocardial damage in patients with moderate to severe CO poisoning.
  • To compare H-FABP levels with cardiac troponin I and echocardiographic findings.
  • To determine the temporal changes of H-FABP and troponin I in CO-poisoned individuals.

Main Methods:

  • Prospective study enrolling 80 patients with severe acute CO intoxication.
  • Serial measurements of serum H-FABP and cardiac troponin I at 0, 6, and 24 hours post-admission.
  • Echocardiography to assess for myocardial wall motion abnormalities, categorizing patients into groups.

Main Results:

  • On admission, 70% of patients had elevated serum H-FABP levels, and 36.3% had elevated troponin I.
  • Patients with wall motion abnormalities showed significantly higher H-FABP levels at 6 and 24 hours (p < 0.01).
  • Serum H-FABP levels decreased over time (p < 0.001), while troponin I levels initially increased then decreased.

Conclusions:

  • Serum H-FABP is a valuable early marker for identifying myocardial damage in CO poisoning.
  • H-FABP levels correlate with echocardiographic evidence of myocardial injury.
  • This biomarker aids in the early assessment of cardiac involvement in carbon monoxide intoxication.
Abstract

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