[Application of convolution curve method for simultaneous determination of four components in somidon]

The computer-aided convolution curve method has been applied to the determination of phenacetin, aminopyrine, caffeine and phenobarbitone in the tablet of somidon without prior separation. The convolution curve method is a compound difference method developed on the basis of Glenn's orthogonal function using computer information treatment technique. The corresponding average recovery and the coefficients of variation were as follows: 99.96, 0.36% for phenacetin; 99.76, 0.43% for aminopyrine; 99.98, 0.48% for caffeine and 99.26, 0.89% for phenobarbitone.