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Updated: May 24, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Published on: January 2, 2015
Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease
Paul S Aisen1, Jeffrey Cummings, Lon S Schneider
1University of California, San Diego, California 92093, USA. paisen@ucsd.edu
Abstract:
In this work we consider marketed drugs for Alzheimer disease (AD) including acetylcholinesterase inhibitors (AChE-Is) and antiglutamatergic treatment involving the N-methyl-d-aspartate (NMDA) receptor. We discuss medications and substances available for use as cognitive enhancers that are not approved for AD or cognitive impairment, and other neurotransmitter-related therapies in development or currently being researched. We also review putative therapies that aim to slow disease progression by mechanisms not directly related to amyloid or tau.
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