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Updated: May 24, 2026
08:15
Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
Published on: January 31, 2020
HIV prevention by oral preexposure prophylaxis
Walid Heneine1, Angela Kashuba
1Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. wheneine@cdc.gov
Cold Spring Harbor Perspectives in Medicine
|March 7, 2012
Summary
Preexposure prophylaxis (PrEP) using antiretroviral drugs is a promising HIV prevention strategy. Daily oral Truvada demonstrated safety and effectiveness in a trial, supporting its use for HIV prevention.
Area of Science:
- Infectious Diseases
- Pharmacology
- Public Health
Background:
- Advances in antiretroviral (ARV) therapy have spurred interest in chemoprophylaxis for HIV prevention.
- Preexposure prophylaxis (PrEP) utilizes ARV drugs in HIV-negative individuals to prevent infection.
- Preclinical and clinical research supports the efficacy of PrEP against HIV.
Purpose of the Study:
- To review preclinical and clinical research on oral preexposure prophylaxis (PrEP) for HIV prevention.
- To discuss pharmacologic considerations and future challenges for oral PrEP.
- To highlight the potential of oral ARV drugs as a novel HIV prevention strategy.
Main Methods:
- Focus on oral administration of ARV drugs for HIV prevention.
- Review of human clinical trials evaluating daily regimens of HIV reverse-transcriptase inhibitors.
- Analysis of data from trials, including one among men who have sex with men.
Main Results:
- Daily Truvada (tenofovir disoproxil fumarate and emtricitabine) was found to be safe and effective in a clinical trial.
- This trial provided the first evidence supporting oral PrEP as a viable prevention strategy.
- Research is ongoing to evaluate different daily regimens of ARV drugs.
Conclusions:
- Oral preexposure prophylaxis (PrEP) shows significant promise as an HIV prevention strategy.
- Further research and clinical trials are necessary to optimize and expand the use of oral PrEP.
- Pharmacologic considerations and addressing future challenges are crucial for successful implementation.
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