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Published on: May 9, 2020
[Homer protein expression after focal brain contusion in rats]
Fu-Yuan Wang1, Ru-Bo Li, Hong-Xia Liang
1Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China. wfy021021@163.com
Objective:
To investigate Homer protein expression after focal brain contusion and explore the relationship between expression and injury time.
Methods:
Focal brain contusion in rats was established and Homer protein expression in brain at different injury intervals after contusion was detected by immunohistochemistry and Western blotting.
Results:
A small amount of Homer positive expression cells were detected in control group, sham operated group and experimental group (0.5 h after contusion). The amount of Homer positive expression cells increased after 3 h and reached peak 12 h after contusion. The amount of positive cells continued to decrease 1 d after contusion and to the base level 7 d after contusion. Homer protein expression based on immunohistochemistry and Western blotting had statistical difference among adjacent groups.
Conclusion:
Expression of Homer protein near the focal contusion area shows time dependence after brain contusion in rats.
