Related Experiment Video
Updated: May 24, 2026
Standardized Rat Coronary Ring Preparation and Real-Time Recording of Dynamic Tension Changes Along Vessel Diameter
Published on: June 16, 2022
[Effect of Tiangou Jiangya capsule on rabbit aortic strip contraction]
Qing Yang1, Yujie Li, Xiaogang Weng
1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Objective:
To observe the effect of Tiangou Jiangya capsule on isolated rabbit aortic strips, and to discuss its antihypertensive mechanism.
Method:
The isolated rabbit aortic strips were placed in perfusion baths, and induced to contract by norepinephrine (NE), KCl and CaCl2 respectively, then Tiangou Jiangya capsule extraction was added to observe its effect on the contraction. The effect on intracellular Ca2+ dependent contraction and extracellular Ca2+ dependent contraction induced by NE were also studied.
Result:
The Tiangou Jiangya capsule (1, 3, 5 g x L(-1)) can reduce the largest contract reaction of aortic strips induced by NE or CaCl2 (P < 0.01). It can reduce both intracellular Ca2+ dependent contraction and extracellular Ca2+ dependent contraction induced by NE (P < 0.01), and the effect on extracellular Ca2+ dependent contraction is more significant. But the Tiangou Jiangya capsule has no significant effect on KCl induced contraction.
Conclusion:
Tiangou Jiangya capsule can regulate intracellular Ca2+ concentration and help to relax the vascular smooth muscle. The mechanism could be regulating the receptor-operated Ca2+ channel. The effect on extracellular Ca2+ dependent contraction is more obvious than on intracellular Ca2+ dependent contraction induced by NE.
