Related Experiment Video
Updated: May 24, 2026
Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
[Experimental studies on toxic effects of Tiangou Jiangya capsule]
Objective:
To study the acute and chronic toxicity of Tiangou Jiangya capsule.
Method:
Tiangou Jiangya capsule was intragastrically administered to mice twice a day. The appearance, behavior, mental status, respiratory changes of mice and the number of poisoned and dead mice in each group were noted daily for 14 consecutive days. The amount of weight and feed of survived mice were recorded every day. The mice were divided into four groups: the treatment groups (minimum, middle, maximum dose of Tiangou Jiangya capsule) and the control group. After continuously orally administrated for 6 months, the rats' behavior, weight gain, food consumption, indications for hematology, blood biochemistry, urine analysis, electrocardiogram, systematic autopsy and histopathology were observed. The above physiological indexes were inspected again 1 month after cease of administration.
Result:
The oral acute toxicity study of Tiangou Jiangya capsule in mice revealed that the maximum dose is 534.86 g x kg(-1), which was 534.86 times the recommended human maximum dose in clinical practice. Compared with normal control group, no significant differences were observed in rats' behaviors, food-intake, electrocardiogram and relative examination indexes among the treatment groups. There was no difference of hematology, biochemistry test, urine and histopathology.
Conclusion:
The minimum dosage of Tiangou Jiangya capsule is relatively safe. It caused weight loss by administrated with the middle and maximum dose for 6 months, which should be paid attention in clinical studies.
Insights
Tiangou Jiangya capsule demonstrated low acute toxicity in mice. Chronic administration at higher doses caused weight loss, suggesting caution in clinical use.
Area of Science:
- Pharmacology
- Toxicology
Context:
- Tiangou Jiangya capsule is a traditional Chinese medicine.
- Understanding its safety profile is crucial for clinical application.
Purpose:
- To evaluate the acute and chronic toxicity of Tiangou Jiangya capsule in animal models.
- To determine the safety margin and potential adverse effects of the capsule.
Summary:
- Acute toxicity studies in mice showed a high maximum tolerated dose, indicating low acute toxicity.
- Chronic administration (6 months) in rats revealed no significant differences in hematology, biochemistry, or histopathology, except for dose-dependent weight loss at middle and maximum doses.
- Physiological parameters remained stable one month after drug cessation.
Impact:
- The minimum dosage of Tiangou Jiangya capsule appears safe.
- Clinicians should monitor for weight loss when using middle and maximum doses.
- This study provides essential safety data for the clinical use of Tiangou Jiangya capsule.
