Related Experiment Video
Updated: May 24, 2026
09:58
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
Published on: June 27, 2020
[Fusion genes and transcripts in neoplasia]
Molekuliarnaia Biologiia
|March 8, 2012
Summary
Chimeric genes, formed by chromosomal rearrangements, are prevalent in tumors and can drive cancer. Understanding their role, including transcription-induced chimerism (TIC), is crucial for developing targeted cancer therapies.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Context:
- Fusion genes arise from chromosomal rearrangements, common in carcinogenesis.
- Over 440 fusion genes are identified in both malignant and benign tumors.
- Transcription-induced chimerism (TIC) generates fusion transcripts in normal tissues, but its oncogenic role is unclear.
Purpose:
- To review and discuss the occurrence and biological relevance of chimeric genes.
- To explore the role of TIC in carcinogenesis.
- To highlight chimeric genes as potential therapeutic targets.
Summary:
- Chimeric genes, resulting from chromosomal rearrangements, are frequent in cancer.
- Hybrid proteins from these genes can serve as specific disease markers and therapeutic targets.
- Their roles vary from primary drivers to facilitators of subclonal selection in tumor evolution.
Impact:
- Provides insights into the biological significance of chimeric genes in various cancers.
- Emphasizes the potential of fusion proteins as diagnostic markers and therapeutic targets.
- Contributes to understanding cancer development and evolution through genetic alterations.
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09:49Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
Published on: July 5, 2019
09:37Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
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