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Genetic polymorphisms of VKORC1, CYP2C9, CYP4F2 in Bai, Tibetan Chinese

W T Zeng1, Q S Zheng, M Huang

  • 1School of Pharmaceutical Sciences, Sun Yat-sen University Guangzhou, China.

Die Pharmazie
|March 8, 2012
PubMed

Insights

Genetic variations in VKORC1, CYP2C9, and CYP4F2 influence warfarin dosing. Bai Chinese individuals exhibit a significantly higher VKORC1 3673G > A A-allele frequency compared to Han Chinese.

Area of Science:

  • Pharmacogenomics
  • Genetic Polymorphisms
  • Drug Metabolism

Background:

  • Warfarin dosing variability is influenced by VKORC1, CYP2C9, and CYP4F2 gene polymorphisms.
  • Existing warfarin dosing algorithms often overlook ethnic-specific genetic variations.
  • Research on warfarin-related gene polymorphisms in Chinese populations has primarily focused on the Han ethnicity.

Purpose of the Study:

  • To investigate common polymorphisms in VKORC1, CYP2C9, and CYP4F2 genes among Bai and Tibetan Chinese populations.
  • To compare these frequencies with those in the Han Chinese population.
  • To inform personalized warfarin dosing strategies for Chinese ethnic minorities.

Main Methods:

  • Polymerase Chain Reaction (PCR)-based methods were employed.
  • Analysis of VKORC1 3673G > A, CYP2C9*3, and CYP4F2 rs2108622 C > T polymorphisms.
  • Genotyping was performed on Han, Bai, and Tibetan Chinese individuals.

Main Results:

  • No statistically significant differences in mutation frequencies were observed for the studied genes across the three ethnic groups.
  • The A-allele frequency for VKORC1 3673G > A was high across all groups (Bai: 92.8%, Tibetan: 90.2%, Han: 90.8%).
  • CYP2C9*3 allele frequency was low in all ethnic groups, and approximately one-fourth of each group carried the mutant T-allele of CYP4F2 rs108622.
  • Bai Chinese demonstrated a statistically significant higher A-allele frequency of VKORC1 3673G > A compared to previously studied Han Chinese.

Conclusions:

  • Bai Chinese individuals possess a significantly higher A-allele frequency for the VKORC1 3673G > A polymorphism.
  • These findings highlight ethnic-specific genetic variations relevant to warfarin pharmacogenomics in China.
  • Further research is warranted to optimize warfarin dosing for diverse Chinese ethnic groups.
Abstract

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