Related Experiment Video
Updated: May 24, 2026

Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyl(tropone)iron
Published on: August 12, 2019
First per-6-O-tritylation of cyclodextrins
Ping Zhang1, Aixia Wang, Lina Cui
1Alberta Glycomics Centre and Department of Chemistry, University of Calgary, 2500, University Drive NW, Calgary, Alberta T2N 1N4, Canada.
Researchers successfully attached a trityl group to every O6 position of cyclodextrin (CD) molecules. A new per-6-substitution method was developed for this complex carbohydrate chemistry.
Area of Science:
- Carbohydrate Chemistry
- Supramolecular Chemistry
Background:
- Cyclodextrins (CDs) are cyclic oligosaccharides with truncated conical structures.
- The steric bulk of the trityl group raises questions about its accessibility to the O6 position of CDs, especially at the narrower end.
Purpose of the Study:
- To investigate the feasibility of per-6-O-tritylation of cyclodextrins.
- To develop a novel synthetic method for modifying the O6 position of all glucopyranosyl units in a cyclodextrin.
Main Methods:
- Development of a novel per-6-substitution reaction.
- Application of the method to cyclodextrin molecules.
Main Results:
- Demonstration that simultaneous tritylation at the O6-position of every glucopyranosyl unit in a cyclodextrin is possible.
- Successful development of a new synthetic strategy for cyclodextrin modification.
Conclusions:
- The steric hindrance posed by the trityl group does not prevent per-6-O-tritylation of cyclodextrins.
- A novel and effective method for per-6-substitution in cyclodextrin chemistry has been established.
More Related Videos
Related Concept Videos
Thermal and Photochemical Electrocyclic Reactions: Overview
Pericyclic Reactions: Introduction
Pericyclic reactions can be classified into three categories: electrocyclic reactions, cycloaddition reactions, and sigmatropic rearrangements. Electrocyclic reactions and sigmatropic rearrangements are...
Cycloaddition Reactions: Overview
Intramolecular Claisen Condensation of Dicarboxylic Esters: Dieckmann Cyclization
Woodward–Hoffmann Selection Rules and Microscopic Reversibility
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation

