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Is there benefit in optimising heart failure treatment in over-80 year-old patients? (HF-80 study): study protocol

Romain Eschalier1, Frédéric Jean, Bruno Pereira

  • 1CHU Clermont-Ferrand, Service Cardiology, F-63000 Clermont-Ferrand. reschalier@chu-clermontferrand.fr

Trials
|March 8, 2012
PubMed

Insights

This study investigates optimizing heart failure treatment for patients over 80. It aims to determine if guideline-adherent care improves quality of life and other outcomes in this elderly population.

Area of Science:

  • Gerontology
  • Cardiology
  • Clinical Trials

Background:

  • Chronic heart failure (HF) is increasing in prevalence due to an aging population and improved disease management.
  • Current HF guidelines are applied to elderly patients (>80 years), but clinical trial data supporting their benefit in this group is lacking.
  • Registries indicate under-prescription of HF treatments in elderly and over-80 populations.

Purpose of the Study:

  • To evaluate the effect of optimizing heart failure management by adhering to international guidelines in patients over 80 years old.
  • To assess the impact of guideline-based care on quality of life, mortality, hospital readmissions, cardiac fibrosis, and economic data in elderly HF patients.

Main Methods:

  • Prospective, randomized, open-label clinical trial with blinded endpoints (HF-80 study).
  • Inclusion of 80 patients aged over 80 admitted with acute heart failure.
  • Comparison of usual care (Group A) versus optimized guideline-adherent management (Group B).

Main Results:

  • Primary endpoint: Quality of life assessed using the Minnesota questionnaire at 6 months.
  • Secondary endpoints: Quality of life, mortality, HF readmissions, cardiac fibrosis, and economic data assessed at 12 months.

Conclusions:

  • Assessing the benefit of guideline-based heart failure management in the over-80 population is crucial due to their fragility.
  • There is a high risk of iatrogenic complications in this demographic, necessitating careful evaluation of treatment strategies.
Abstract

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